FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
PORTNOY DAVID
   2. Issuer Name and Ticker or Trading Symbol
CRYO CELL INTERNATIONAL INC [CCEL] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Chairman, Co-CEO
(Last)
(First)
(Middle)
700 BROOKER CREEK BLVD, SUITE 1800		 3. Date of Earliest Transaction (Month/Day/Year)
05/13/2021
(Street)

OLDSMAR, FL 34677		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock               102,586 I By Spouse
Common Stock               97,216 I By 401K
Common Stock 05/13/2021   P   2,000 A $ 8.55 514,972 D  
Common Stock               152,724 I By Corporation (1)
Common Stock               15,611 I as Custodian for Daughter
Common Stock               9,974 I As Custodian for Son (2)
Common Stock               59,027 I By LLC
Common Stock               199,080 I By IRA
Common Stock               55,219 I By Corporation
Common Stock               11,252 I As Custodian for Son
Common Stock               11,242 I As Custodian for Son
Common Stock               10,783 I As Custodian for Son
Common Stock               9,122 I As Custodian for Daughter

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option $ 1.72             12/01/2011 12/01/2021 Common Stock 200,000   200,000 D  
Stock Option $ 2.9             08/31/2011 08/31/2021 Common Stock 100,000   100,000 D  
Stock Option $ 3.14             04/15/2016(3) 04/15/2026 Common Stock 70,270   70,270 D  
Stock Option $ 7.92             03/08/2013(4) 03/08/2023 Common Stock 23,636   23,636 D  
Stock Option $ 7.53             08/30/2019(5) 08/30/2029 Common Stock 26,243   26,243 D  
Stock Option $ 7.28             12/20/2019(6) 12/20/2029 Common Stock 23,636   23,636 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
PORTNOY DAVID
700 BROOKER CREEK BLVD
SUITE 1800
OLDSMAR, FL 34677		   X     Chairman, Co-CEO  

Signatures

 /s/ David Portnoy   05/18/2021
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Shares of Common Stock held by Mayim Investment Limited Partnership as is David I. Portnoy my be deemed the beneficial owner as the managing member and owner of Mayim Management, LLC, which is the general partner of Mayim Management Limited Partnership, which is the general partner of Mayim Investment Limited Partnership.
(2) Shares of Common Stock held by uTIPu, Inc., as to which David I. Portnoy may be deemed the beneficial owner as the Chairman of the Board and Secretary.
(3) Stock options vest 1/3 on the date of grant, 1/3 on December 1, 2016 and 1/3 on December 1, 2017.
(4) Stock Options will vest 1/3 on the date of grant, 1/3 on December 1, 2018 and 1/3 on December 1, 2019.
(5) Stock options will vest 1/3 on the date of grant, 1/3 on December 1, 2019 and 1/3 on December 1, 2020.
(6) Stock options will vest 1/3 on the date of grant, 1/3 on December 1, 2020 and 1/3 on December 1, 2021.

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