FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Portnoy Mark L.
   2. Issuer Name and Ticker or Trading Symbol
CRYO CELL INTERNATIONAL INC [CCEL] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director __X__ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Co-CEO
(Last)
(First)
(Middle)
700 BROOKER CREEK BLVD, SUITE 1800		 3. Date of Earliest Transaction (Month/Day/Year)
04/08/2022
(Street)

OLDSMAR, FL 34677		 4. If Amendment, Date Original Filed(Month/Day/Year)
12/22/2022		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock               42,266 I By 401K
Common Stock               71,529 I By Partnership (1)
Common Stock               762,514 D  

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option $ 3.14             04/15/2016 04/15/2026 Common Stock 59,459   59,459 D  
Stock Option $ 7.92             03/08/2018 03/08/2028 Common Stock 20,000   20,000 D  
Stock Option $ 7.53             08/30/2019 08/30/2029 Common Stock 22,222   22,222 D  
Stock Option $ 7.28             12/20/2019(2) 12/20/2029 Common Stock 20,000   20,000 D  
Stock Option $ 13.5 12/22/2021   D     20,000 12/22/2021 12/22/2024 Common Stock 20,000 $ 13.5 0 D  
Stock Option $ 12.27 12/22/2021   D(3)     100,000 12/22/2021 12/22/2028 Common Stock 100,000 $ 12.27 0 D  
Stock Option $ 13.5 04/08/2022   A(4)   20,000   12/22/2022(5) 12/22/2024 Common Stock 20,000 $ 13.5 20,000 D  
Stock Option $ 12.27 04/08/2022   A(4)   100,000   12/22/2022(6) 12/22/2028 Common Stock 100,000 $ 12.27 100,000 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Portnoy Mark L.
700 BROOKER CREEK BLVD
SUITE 1800
OLDSMAR, FL 34677		   X   X   Co-CEO  

Signatures

 /s/ Mark Portnoy   04/14/2022
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Shares of Common Stock held by Capital Asset Fund #1 Limited Partnership, as to which Mark L. Portnoy may be deemed the beneficial owner as its general partner.
(2) Stock options will vest 1/3 on the date of grant, 1/3 on December 1, 2020 and 1/3 on December 1, 2021.
(3) On April 8, 2022, the stock options were cancelled by mutual agreement of the reporting person and the issuer.
(4) The stock options are subject to the approval of the 2022 Equity Incentive Plan, which vote is expected to occur at the Company's 2022 Annual Meeting.
(5) One-third of the stock options will vest on December 22, 2022, one-third will vest on January 22, 2023 and one-third on January 22, 2024.
(6) Stock options vest immediately when the price of the Company's stock reaches $25.00 per share during the seven-year option term.

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